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The Holistic approach for Prevention, controlling and Treatment of Candida Albicans Overgrowth – Healing the intestinal membrane

http://kylejnorton.blogspot.com/2015/03/the-holistic-approach-for-prevention_18.html

Wednesday, 18 March 2015
The Holistic approach for Prevention, controlling and Treatment of Candida Albicans Overgrowth – Healing the intestinal membrane

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

What is Candida Albicans
Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract. In fact, under normal circumstances, Candida albicans that does not cause harmful effects, but overgrowth results in candidiasis. Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1). According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.

Treatments and controllings

Healing the intestinal membrane
1. L-glutamine
L-glutamine is one of the 20 amino acids encoded by the standard genetic code and used to treat certain gastrointestinal disorders(342)(343) by serving as a source of fuel for the cells that line the gastrointestinal tract. According to Ankara University, L-glutamine inhibited the over growth of candida through its antimutagenic and antimicrobial activities(344).

2. N-acetyl-glucosamine
N-acetyl-glucosamine is a monosaccharide derivative of glucose that supports the digestive track function and maintains healthy intestinal lining by stimulating cell growth in the intestinal track(345). According to 1National Institute of Plant Genome Research, GIG2 (GlcNAc-induced gene 2). involved in the metabolism of N-acetylneuraminate (sialic acid), effectively decrease in fungal burden in mouse model(346).

3. Rice-bran oil
Rice-bran oil, extracted from the germ and inner husk of rice, containing a compound gamma-oryzanol(347) showed to reduce the risk of gastric ulcers caused by stress while at the same time maintaining gastrointestinal motility(348). According to Manipal Academy of Higher Education (Deemed University, rice bran oil immobilized lipase from Candida, a potential pathway for fungal overgrowth(349).

4. Pancreatic enzymes products
Pancreatic enzymes allow for more bacteria to grow in the intestine enabling the food to be digested a lot easier(350). it can be found as supplements and in certain foods. Insufficient pancreatic enzymes can quickly encourage Candida overgrowth the digestive tracts(351).

5. Butyric acid
Butyric acid, a fatty acid occurring in the form of esters in animal fats and plant oils, has found to be effective in inhibited pathogenic organisms(352), improved digestion and promoted intestinal health(353) by producing bacteria to feed on lactic acid, then multiplying and revving up their production(354) . Butyric acid also consists anti-inflammatory property(355) and strengthens the intestinal mucosal barrier.(356).

5. Fructo-oligosaccharides(FOS)
Fructo-oligosaccharides(FOS) is a class of oligosaccharides used as an artificial or alternative sweetener(357), extracted from fruits and vegetables such as bananas, onions, chicory root, garlic, asparagus, barley, wheat, tomatoes, and leeks(358). It is inulin-type prebiotics(359), stimulated the growth of friendly bacteria in the intestine track to counter react to other bad bacteria(360)(362) such as candida but it may cause gas formation, through increasing faecal biomass and water content of the stools, for improvement of bowel habits(361)

6. Etc.

+ References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(342) Glutamine supplementation for young infants with severe gastrointestinal disease. by Brown JV1, Moe-Byrne T, McGuire W.(PubMed)
(343) Glutamine and intestinal barrier function ,By Wang B1, Wu G, Zhou Z, Dai Z, Sun Y, Ji Y, Li W, Wang W, Liu C, Han F, Wu Z.(PubMed)
(344) Schiff bases attached L-glutamine and L-asparagine: first investigation on antimutagenic and antimicrobial analyses by Sakiyan I1, Anar M, Oğütcü H, Agar G, Sarı N.(PubMed)
(345)Explore The Truth On Cures For Yeast Infection(Thing for Ladies)
(346) and maintains healthy intestinal lining(Thing for Ladies)
(347) Role of gamma-oryzanol in drought-tolerant and susceptible cultivars of rice (Oryza sativa L.) by Kumar MS, Dahuja A, Rai RD, Walia S, Tyagi A.(PubMed)
(348) [Effects of gamma-oryzanol on gastric lesions and small intestinal propulsive activity in mice].
[Article in Japanese] by Ichimaru Y, Moriyama M, Ichimaru M, Gomita Y.(PubMed)
(349) Hydrolysis of rice bran oil using an immobilized lipase from Candida rugosa in isooctane by Murty VR1, Bhat J, Muniswaran PK.(PubMed)
(350) The use of dual-isotope imaging to compare the gastrointestinal transit of food and pancreatic enzyme pellets in cystic fibrosis patients by Hillel PG1, Tindale WB, Taylor CJ, Frier M, Senior S, Ghosal S.(PubMed)
(351) The Best Digestive Enzymes For Candida(Digestive health Guide)
(352) Purification and characterization of antibacterial substances produced by a marine bacterium Pseudoalteromonas haloplanktis strain by Hayashida-Soiza G1, Uchida A, Mori N, Kuwahara Y, Ishida Y.(PubMed)
(353) Induction of rhythmic transient depolarizations associated with waxing and waning of slow wave activity in intestinal smooth muscle by Pawelka AJ1, Huizinga JD2.(PubMed)
(354) Fermentation Analysis & Evaluation(daily one)
(355) Anti-inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL-12 and up-regulation of IL-10 production by Säemann MD1, Böhmig GA, Osterreicher CH, Burtscher H, Parolini O, Diakos C, Stöckl J, Hörl WH, Zlabinger GJ.(PubMed)
(356) Inhibition of p38 mitogen-activated protein kinase attenuates butyrate-induced intestinal barrier impairment in a Caco-2 cell monolayer model by Huang XZ1, Li ZR, Zhu LB, Huang HY, Hou LL, Lin J.(PubMed)
(357) Functional characterization of sucrose phosphorylase and scrR, a regulator of sucrose metabolism in Lactobacillus reuteri by Teixeira JS1, Abdi R, Su MS, Schwab C, Gänzle MG.(PubMed)
(358) Fructo-oligosaccharides(FOS)(Wikipedia)

(359) [Synthesis of novel fructo-oligosaccharides (FOS) by enzymatic reaction].[Article in French]by Grizard D1, Barthomeuf C.(PubMed)
(360) Inulin-type prebiotics–a review: part 1 by Kelly G.(PubMed)
(361) Introducing inulin-type fructans by Roberfroid MB1.(PubMed)
(362) Studies with Inulin-Type Fructans on Intestinal Infections, Permeability, and Inflammation,
by Francisco Guarner(The Journal of Nutrition)

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Ask Dr. Manny: Eat Fruits and Vegetables to Prevent Osteoporosis

http://www.askdrmanny.com/2015/01/26/eat-fruits-and-vegetables-to-prevent-osteoporosis/

Eat Fruits and Vegetables to Prevent Osteoporosis
January 26, 2015

Fresh Vegetables – Potatoes, Tomatoes.
Osteoporosis is a debilitating disease in which bones lose calcium and minerals and become fragile and less dense. People with osteoporosis have bones with a high likelihood of being fractured. Women are especially at risk for osteoporosis. There is an estimated 200 million women worldwide affected by this condition.

Bone Resorption
The University of Surrey in the United Kingdom recently published research that found bicarbonate and citrate, which are potassium salts, improve bone health. These important potassium salts increase bone strength by reducing bone resorption, the process by which bones are broken down when minerals are released from the bones to the blood. Normally, bone resorption is a natural process where bones grow, heal, and adapt. However, in osteoporosis, the rate at which bones are broken down is much higher than the rate at which they are built back up. Since potassium salts reduce bone resorption, having a high intake of these salts may prevent osteoporosis.

A typical Western diet consists of a large amount of animal and cereal proteins. This type of eating results in high levels of acid in the body. This is bad news as excess acid weakens bones and allows them to fracture more easily. Another positive effect of potassium salts is they greatly reduce the amount of calcium and acid excreted in urine. According to researchers at the University of Surrey, this simply means that excess acid in the body is neutralized while bone mineral is also preserved.

Recommended Daily Values
What foods are high in potassium salts? Researchers recommend eating more fruits and vegetables to strengthen bones. Vegetables that are high in potassium include potatoes, dark leafy greens such as spinach and Swiss chard, squash, and mushrooms. Potassium rich fruits include bananas, tomatoes, avocado, and apricots. Some other potassium rich foods are yogurt and fish such as salmon and cod. As you can see, potassium is quite a plentiful nutrient in many foods that can be added to your daily eating routine. To know how to get enough potassium in your diet, it’s helpful to understand just how much of these foods you need to be eating. An average banana provides 12% of your recommended Daily Value (DV) of potassium, or the same as a cup of sliced white mushrooms that can easily be used to top your salad. A 3 ounce fillet of salmon provides 16% of your DV. A cup of yogurt has 18% DV, and a cup of cooked spinach has 26% DV. The recommended daily value for potassium is 3.5 grams, but it’s not a bad idea to aim for a bit higher than that to help maintain bone density and lower your risk of osteoporosis.

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The Top Four Anti-Inflammatory Spices (cloves, ginger, rosemary, turmeric)

http://nutritionfacts.org/2015/01/20/the-top-four-anti-inflammatory-spices/

The Top Four Anti-Inflammatory Spices
Written by: Michael Greger M.D. on January 20th, 2015
The Top Four Anti-Inflammatory Spices
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Once in a while I come across a study that’s so juicy I have to do a whole video about it (Which Spices Fight Inflammation?).

A group of researchers at the University of Florida, Gainesville and Pennsylvania State set up a brilliant experiment. We’ve known that ounce per ounce, herbs and spices have some of the greatest antioxidant activities known. But that’s only ever been tested in a test tube. Before we can ask if an herb or spice has real health benefits, it is first necessary to determine whether it is bioavailable — whether the active ingredients are even absorbed. This had never been done, until now.

The researchers could have taken the easy route and just measured the change in antioxidant level in one’s bloodstream before and after consumption, but the assumption that the appearance of antioxidant activity in the blood is an indication of bioavailability has a weakness. Maybe more gets absorbed than we think but doesn’t show up on antioxidant tests because it gets bound up to proteins or cells. So the researchers attempted to measure physiological changes in the blood. They were interested in whether absorbed compounds would be able to protect white blood cells from an oxidative or inflammatory injury—whether herb and spice consumption would protect the strands of our DNA from breaking when attacked by free radicals. I cover the DNA findings in my video, Spicing Up DNA Protection. They also wondered if the consumption might alter cellular inflammatory responses in the presence of a physiologically relevant inflammatory insult. What does this all mean?

The researchers took a bunch of people and had each of them eat different types of spices for a week. There were many truly unique things about this study, but one was that the quantity of spices that study subjects consumed was based on the usual levels of consumption in actual food. For example, the oregano group was given a half teaspoon a day—a practical quantity that people might actually eat once in a while. At the end of the week, they drew blood from the dozen or so people they had adding, for example, black pepper to their diets that week, and compared the effects of their blood to the effects of the blood of the dozen subjects on cayenne, or cinnamon, or cloves, or cumin. They had about ten different groups of people eating about ten different spices. Then they dripped their plasma (the liquid fraction of their blood) onto human white blood cells in a Petri dish that had been exposed to an inflammatory insult. The researchers wanted to pick something really inflammatory, so they chose oxidized cholesterol (which is what we’d get in our bloodstream after eating something like fried chicken. If oxidized cholesterol is a new concept for you, please check out its role in heart disease progression in my video Arterial Acne). So they jabbed the white blood cells with oxidized cholesterol and measured how much tumor necrosis factor (TNF) they produced in response.

TNF is a powerful inflammatory cytokine, infamous for the role it plays in autoimmune attacks like inflammatory bowel disease. Compared to the blood of those who ate no spices for a week, black pepper was unable to significantly dampen the inflammatory response. What about any of the other spices? The following significantly stifled the inflammatory response:

cloves
ginger
rosemary
turmeric

And remember, they weren’t dripping the spices themselves on these human white blood cells, but the blood of those who ate the spices. So the results represents what might happen when cells in our body are exposed to the levels of spices that circulate in our bloodstream after normal daily consumption—not megadoses in some pill. Just the amount that makes our spaghetti sauce, pumpkin pie, or curry sauce taste good.

There are drugs that can do the same thing. Tumor necrosis factors are such major mediators of inflammation and inflammation-related diseases that there are TNF-blocking drugs on the market for the treatment of inflammatory diseases such as osteoarthritis, inflammatory bowel disease, psoriasis, and ankylosing spondylitis, which collectively rake in more than $20 billion a year ($15,000–$20,000 per person per year). At that price, the side effects better be hugs and rainbows. But no, the drugs carry a so-called “black box warning” because they can cause things like cancer and heart failure. If only there was a cheaper, safer solution.

The spice curcumin, the yellow pigment in turmeric, is substantially cheaper and safer, but does it work outside of a test tube? There’s evidence that it may help in all of the diseases for which TNF blockers are currently being used. So with health-care costs and safety being such major issues, this golden spice turmeric may help provide the solution.

See Antioxidants in a Pinch and How to Reach the Antioxidant RDA to see the extent to which even small amounts of spices can affect one’s antioxidant intake.

Another elegant series of “ex vivo” experiments exploring the cancer fighting power of lifestyle changes can be seen in the videos starting with Ex Vivo Cancer Proliferation Bioassay.

Mushrooms (Boosting Immunity While Reducing Inflammation), nuts (Fighting Inflammation in a Nut Shell), and purple potatoes (Anti-Inflammatory Effects of Purple Potatoes) may also reduce inflammation (along with plant foods in general, see Anti-Inflammatory Antioxidants and Aspirin Levels in Plant Foods). In fact so well that plant-based diets can be used to treat inflammatory conditions. See, for example, Dietary Treatment of Crohn’s Disease, Diet & Rheumatoid Arthritis, and Potassium and Autoimmune Disease. Animal products on the other hand may increase inflammation through a variety of mechanisms, including endotoxins (How Does Meat Cause Inflammation?), arachidonic acid (Chicken, Eggs, and Inflammation), and Neu5Gc (The Inflammatory Meat Molecule Neu5Gc).

-Michael Greger, M.D

PS: If you haven’t yet, you can subscribe to my free videos here and watch my live year-in-review presentations Uprooting the Leading Causes of Death, More Than an Apple a Day, and From Table to Able.

Image Credit: jo-marshall (was Jo-h) / Flickr

Tags: alternative medicine, ankylosing spondylitis, antioxidants, autoimmune diseases, cancer, cancer survival, cardiovascular disease, cardiovascular health, Cayenne pepper, chicken, cholesterol, cinnamon, cloves, complementary medicine, cost savings, cumin, curcumin, DNA damage, ginger, heart disease, heart failure, heart health, herbs, inflammation, inflammatory bowel disease, medications, oregano, osteoarthritis, oxidative stress, pepper, poultry, psoriasis, rosemary, side effects, spices, Tumor necrosis factor, turmeric


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Surprising Symptoms of Prediabetes

http://bottomlinehealth.com/surprising-symptoms-of-prediabetes/

Surprising Symptoms of Prediabetes
Published February 1, 2010 Publication Bottom Line Health Source Frederic Vagnini MD Print
1938
ITCHY SKIN…SLOW-HEALING CUTS…TENDER GUMS…AND MORE

One of the best ways to prevent diabetes is to spot blood sugar (glucose) problems before the full-blown disease develops. But most people don’t realize that diabetes — and its precursor, prediabetes — can cause no symptoms at all or a wide range of symptoms that often are misinterpreted.

Common mistake: Because diabetes is strongly linked to excess body weight, many people who are a normal weight assume that they won’t develop the disease. But that’s not always true. About 15% of people who are diagnosed with diabetes are not overweight. And paradoxically, even weight loss can be a symptom of this complex disorder in people (normal weight or overweight) who have uncontrolled high glucose levels.

Shocking new finding: The Centers for Disease Control and Prevention now estimates that 40% of Americans ages 40 to 74 have prediabetes, and nearly two out of three Americans over age 65 have prediabetes or diabetes — most likely due to the increasing numbers of people who are overweight and inactive, both of which boost diabetes risk.

However, most primary care doctors aren’t diagnosing and treating prediabetes early enough in their patients — often because they fail to order the necessary screening tests. And because the symptoms of prediabetes can be subtle, especially in its early stages, most people are not reporting potential red flags to their doctors.

Fortunately, prediabetes can virtually always be prevented from progressing to diabetes if the condition is identified and treated in its early stages (by following a healthful diet, exercising regularly and taking nutritional supplements and medications, if necessary).

RED FLAGS FOR DIABETES

Being overweight (defined as having a body mass index, or BMI, of 25 or higher) is perhaps the best-known risk factor for diabetes.* The more excess body weight you have, the more resistant your cells become to the blood sugar–regulating effects of the hormone insulin, ultimately causing blood glucose levels to rise.

Greatest danger: Abdominal fat, in particular, further boosts diabetes risk. That’s because belly (visceral) fat hinders the processing of insulin. The single biggest risk factor for prediabetes is having a waistline of 40 inches or more if you’re a man… or 35 inches or more if you’re a woman. Lesser-known red flags for prediabetes (and diabetes) — if you have one of these symptoms, see your doctor…

Increased thirst and need to urinate. Because excess blood glucose draws water from the body’s tissues, people with elevated blood glucose levels feel thirsty much of the time. Even when they drink fluids, their thirst is rarely quenched. Therefore, they drink even more, causing them to urinate more often than is normal for them.
Unexplained weight loss. While being overweight is a significant risk factor for prediabetes, the condition also can paradoxically lead to unexplained weight loss resulting from a lack of energy supply to the body’s cells and a loss of glucose-related calories due to excessive urination.
Dry, itchy skin. Excess blood glucose also draws moisture from the skin, leaving it dry and prone to itching and cracking — especially on the legs, feet and elbows.
Blurred vision. When excess blood glucose draws fluids from the body, this can dehydrate the lenses of the eyes, making it difficult to focus properly.
Slow-healing cuts, sores or bruises and frequent infections. For unknown reasons, excess blood glucose appears to interfere with the body’s healing processes and its ability to fight off infection. In particular, women with prediabetes and diabetes are prone to urinary tract and vaginal infections.
Red, swollen and tender gums. Because the body’s ability to heal can be compromised by prediabetes, gum inflammation, involving red, swollen, tender and/or bleeding gums, may develop.
Persistent feelings of hunger. When the body’s cells don’t get enough glucose due to prediabetes, the cells send signals to the brain that are interpreted as hunger, typically about one hour after consuming a meal.
Lack of energy. Because their cells are starved of energy-boosting glucose, people with prediabetes tend to tire quickly after even mild physical effort. Dehydration due to excess blood glucose also can contribute to fatigue.
Falling asleep after eating. An hour or so after eating, our digestive systems convert the food we’ve eaten into glucose. In people with prediabetes, the process is exaggerated — blood glucose levels spike, triggering a surge of insulin as the body attempts to stabilize high glucose levels. This insulin surge is ineffective in lowering blood glucose, causing the person to become drowsy. If you feel sleepy after meals, it can be a sign that your blood glucose levels are riding this prediabetic roller coaster.
Moodiness and irritability. Lack of energy production in your cells, together with sharp rises and dips in blood glucose levels, can trigger feelings of restlessness, irritability and exaggerated emotional responses to stress.
Tingling or numbness in the hands and feet. Excess blood glucose can damage small blood vessels feeding the body’s peripheral nerves, often causing tingling, loss of sensation or burning pain in the hands, arms, legs or feet.
Loss of sex drive and erectile dysfunction in men. Prediabetes is associated with low testosterone in men, which often reduces libido. In addition, glucose-related damage to the body’s small blood vessels often impairs the ability of prediabetic men to have an erection.
What Is PREDIABETES?

Prediabetes occurs when the body’s cells no longer respond correctly to insulin, a hormone that regulates blood sugar. With prediabetes, blood sugar levels are higher than normal but not high enough to warrant a diagnosis of diabetes.

Prediabetes affects about 57 million Americans — most of whom are unaware that they have the condition.

Three Key Diabetes Tests

If you suspect that you may have prediabetes, ask your doctor to order the following tests…

Fasting blood glucose. This traditional blood test for diabetes is usually part of a standard physical. Until recently, a result over 125 mg/dL was considered a sign of diabetes, while 100 mg/dL to 125 mg/dL indicated prediabetes.

New finding: Standard guidelines established by the American Diabetes Association have not changed, but recent data suggest that a person who has a fasting blood glucose reading over 90 mg/dL should be evaluated by a physician.

Hemoglobin A1C. This blood test, also included in many annual checkups, measures the average blood glucose level over a two- to three-month period. An A1C result of 4.5% to 5.9% is considered normal… 6% to 6.5% indicates prediabetes… and two separate readings of 6.5% or above indicate diabetes.

New danger level: Standard guidelines still use 6% as the lower end of the prediabetes range, but recent data suggest that results as low as 5.6% or 5.7% may signal prediabetes.

Oral glucose tolerance test. Administered over two hours in your doctor’s office, this test can spot problems with blood sugar regulation that may not show up in the other tests. For the oral glucose tolerance test, blood levels of glucose are checked immediately before drinking a premixed glucose formula and two hours afterward.

A result of 140 mg/dL to 159 mg/dL is a sign of increased risk for diabetes… 160 mg/dL to 200 mg/dL indicates high risk for diabetes… and over 200 mg/dL signals full-blown diabetes. Also ask your doctor to measure your insulin levels—insulin fluctuations can be an even earlier predictor of prediabetes than the tests described above.

*For a BMI calculator, go to the Web site of the National Heart, Lung and Blood Institute, http://www.nhlbi.nih.gov/bmi

Source: Frederic Vagnini, MD, a cardiovascular surgeon and medical director of the Heart, Diabetes and Weight Loss Centers of New York in New York City. He is coauthor of The Weight Loss Plan for Beating Diabetes (Fair Winds).


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Health Benefits of Passion Fruit Seeds

http://www.healwithfood.org/health-benefits/passion-fruit-seeds.php

Health Benefits of Passion Fruit Seeds

Can you eat passion fruit seeds, and if so, do they offer any health benefits? This question is commonly asked by health food enthusiasts eager to explore the benefits of exotic fruits. The brief answer is: yes, passion fruit seeds are edible, and they are good for you, too. Passion fruit seeds provide a nice crunch when eaten with the fruit pulp, and they deliver an abundance of nutritional and health benefits ranging from antioxidant protection to the maintenance of healthy cardiovascular and intestinal systems. They are rich in polyphenolic compounds such as piceatannol and scirpusin B, and they deliver plenty of insoluble dietary fiber and magnesium. In this article, we will take an in-depth look into the multiple nutritional and health benefits of passion fruit seeds.

Passion Fruit Seeds
Piceatannol and scirpusin B in passion fruit seeds provide antioxidant protection

Passion fruit seeds are loaded with piceatannol and scirpusin B, polyphenolic compounds that have strong antioxidant activity. Antioxidants are thought to protect the body from free radicals, highly reactive molecules that damage the DNA within cells.

The damage caused by free radicals can ultimately lead to many degenerative and chronic diseases such as immune system problems, atherosclerosis, Alzheimer’s disease, heart disease, arthritis, dementia, and diabetes. In addition to providing protection against certain diseases, the free radical destroying properties of passion fruit seeds may also provide beauty benefits by preventing premature wrinkling of the skin caused by UV radiation. In response to exposure to UV rays your body produces large amounts of enzymes called metalloproteinases which help repair sun-damaged collagen. However, not all metalloproteinases are good for us. Some of them actually degrade collagen and elastin — which can eventually lead to wrinkling of the skin — and free radicals activate these harmful metalloproteinases.

Passion fruit seeds may offer significant cardiovascular benefits

Sano, Sugiyama, Ito, Katano, and Ishihata (2011) investigated the vasorelaxing effects of the major polyphenols found in passion fruit seeds. Vasorelaxation refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the blood vessel walls. This widening of blood vessels leads to a decrease in vascular pressure which is important for a healthy cardiovascular system. The researchers found that both piceatannol and scirpusin B offered potent vasorelaxant effects in rat aortas3 (aorta is the large artery that carries oxygen-rich blood from the heart). While both of these compounds offered cardiovascular health benefits, scirpusin B exerted a greater vasorelaxant effect.

Tip: Check out our page on heart healthy diet tips for nutrition advice, food recommendations and recipes designed for people who want to reduce their risk of developing a cardiovascular disease (CVD) by eating and avoiding specific foods.

Passion fruit seeds deliver magnesium

Passion fruit seeds provide magnesium, an essential mineral that plays a prominent role in your health from the day you are born. For starters, magnesium plays an important role in carbohydrate metabolism. It also is essential for proper heartbeat and nerve transmission. Furthermore, it helps genes function properly. Still not impressed with the health effects of magnesium? Well, guess what, magnesium is also necessary for strong bones. The Recommended Daily Allowance (RDA) for magnesium in adults ranges from 310 to 420 milligrams, and a regular consumption of passion fruit seeds can make a significant contribution to your daily magnesium intake. Eating plenty of magnesium-rich foods is particularly important to people with an increased risk of magnesium deficiency. Risk factors that increase the likelihood of magnesium deficiency include stress, long-term use of certain diuretics, some gastrointestinal disorders such as Crohn’s disease, and high alcohol consumption.

The insoluble fiber in passion fruit seeds promotes intestinal health

Passion fruit seeds are rich in insoluble dietary fiber (64.1 grams per 100 grams)1. Chau, Huang, and Chang (2005) have suggested that the passion fruit seeds’ insoluble fiber might offer an effective functional ingredient to promote intestinal function and health2. They found that adding passion fruit seeds’ insoluble fiber to a fiber-free diet could enhance the intestinal amylase activity and reduce the caecal pH and caecal ammonia content. Amylase is an important enzyme needed to convert complex sugars into simple sugars during digestion. A decrease in caecal pH and caecal ammonia in turn helps balance bacteria in the intestines and potentially reduce the risk of tumors in the colon. Additionally, insoluble fiber helps promote regular bowel movement and prevent constipation and hemorrhoids. It also helps transport toxins out of the body.

References
1. Chau, C., Huang, Y. (2004). Characterization of passion fruit seed fibers — a potential fiber source. Food Chemistry, 85(2), 189-194
2. Chau, C., Huang, Y., & Chang, F. (2005). Effects of fiber derived from passion fruit seed on the activities of ileum mucosal enzymes and colonic bacterial enzymes in hamsters. Journal of the Science of Food and Agriculture, 85(12), 2119-2124
3. Sano S, Sugiyama K, Ito T, Katano Y, & Ishihata A. (2011). Identification of the strong vasorelaxing substance scirpusin B, a dimer of piceatannol, from passion fruit (Passiflora edulis) seeds. Journal of Agricultural and Food Chemistry, 59(11), 6209-6213.

Source: http://www.healwithfood.org/health-benefits/passion-fruit-seeds.php#ixzz3PD5a9Jhz


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9 Signs You Have A Leaky Gut

http://www.amymyersmd.com/2013/09/12/9-signs-you-have-a-leaky-gut/

9 Signs You Have A Leaky Gut

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9 Signs You Have A Leaky Gut

The gut is the gateway to health. If your gut is healthy, chances are that you’re in good health. However, there’s a condition called leaky gut that can lead to a host of health problems.

What is a leaky gut?
The gut is naturally permeable to very small molecules in order to absorb these vital nutrients. In fact, regulating intestinal permeability is one of the basic functions of the cells that line the intestinal wall. In sensitive people, gluten can cause the gut cells to release zonulin, a protein that can break apart tight junctions in the intestinal lining. Other factors — such as infections, toxins, stress and age — can also cause these tight junctions to break apart. Once these tight junctions get broken apart, you have a leaky gut. When your gut is leaky, things like toxins, microbes, undigested food particles, and more can escape from your intestines and travel throughout your body via your bloodstream. Your immune system marks these “foreign invaders” as pathogens and attacks them. The immune response to these invaders can appear in the form of any of the nine signs you have a leaky gut, which are listed below.

What causes leaky gut?
The main culprits are foods, infections, and toxins. Gluten is the number one cause of leaky gut. Other inflammatory foods like dairy or toxic foods, such sugar and excessive alcohol, are suspected as well. The most common infectious causes are candida overgrowth, intestinal parasites, and small intestine bacterial overgrowth (SIBO). Toxins come in the form of medications, including NSAIDS like Motrin and Advil, steroids, antibiotics, and acid-reducing drugs. They can also present in the form of environmental toxins like mercury, pesticides and BPA from plastics. Stress and age also contribute to a leaky gut. If you suffer from any of the following conditions, it’s likely that you have a leaky gut.

9 Signs You Have a Leaky Gut

1. Digestive issues such as gas, bloating, diarrhea or irritable bowel syndrome (IBS).

2. Seasonal allergies or asthma.

3. Hormonal imbalances such as PMS or PCOS.

4. Diagnosis of an autoimmune disease such as rheumatoid arthritis, Hashimoto’s thyroiditis, lupus, psoriasis, or celiac disease.

5. Diagnosis of chronic fatigue or fibromyalgia.

6. Mood and mind issues such as depression, anxiety, ADD or ADHD.

7. Skin issues such as acne, rosacea, or eczema.

8. Diagnosis of candida overgrowth.

9. Food allergies or food intolerances.

How do you heal a leaky gut?

In my practice, I have all of my patients follow The Myers Way comprehensive elimination diet, which removes the toxic and inflammatory foods for a certain period of time. In addition, I have them follow a 4R program to heal their gut. The 4R program is as follows.

1. Remove.
Remove the bad. The goal is to get rid of things that negatively affect the environment of the GI tract, such as inflammatory and toxic foods, and intestinal infections.

2. Replace.
Replace the good. Add back the essential ingredients for proper digestion and absorption, such as digestive enzymes, hydrochloric acid and bile acids.

3. Reinoculate.
It’s critical to restore beneficial bacteria to reestablish a healthy balance of good bacteria.

4. Repair.
It’s essential to provide the nutrients necessary to help the gut repair itself. One of my favorite supplements is L-glutamine, an amino acid that helps to rejuvenate the lining of the gut wall. If you still have symptoms after following the above recommendations, I would recommend finding a Functional Medicine physician in your area to work with you and to order a comprehensive stool test.

Learn more about my approach to healing the gut in The Autoimmune Solution! Order before January 27th and receive free gifts.


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ADHD drug could be the answer for binge eating disorder, study says

http://www.foxnews.com/health/2015/01/14/adhd-drug-could-be-answer-for-binge-eating-disorder-study-says/?intcmp=ob_homepage_health&intcmp=obnetwork

ADHD drug could be the answer for binge eating disorder, study says

By Colleen CapponPublished January 14, 2015FoxNews.com

An estimated 4 million Americans suffer from binge eating disorder (BED), or recurrent episodes of excessive food consumption that can lead to numerous health problems. A new clinical trial shows a popular drug used to treat attention-deficit/hyperactivity disorder (ADHD) is effective in combating BED.

Researchers at the Lindner Center of Hope Research Institute in Mason, Ohio, compared the ADHD drug lisdexamfetamine with a placebo in more than 500 adults with moderate to severe BED in a randomized clinical trial from May 2011 through January 2012. The medication was administered in dosages of 30, 50 or 70 mg/day or a placebo. The U.S. Food and Drug Administration (FDA) approved Lisdexamfetamine in 2007 to treat ADHD.

Lead researcher Dr. Susan McElroy told FoxNews.com the team decided on doing a trial with lisdexamfetamine specifically because both BED and ADHD can show signs of excessive impulsivity, obesity and dopamine dysfunction.

“In studies of ADHD, lisdexamfetamine improved impulsive symptoms and reduced hunger,” McElroy said. “BED is characterized by increased impulsivity and increased hunger, and animal studies suggested drugs like lisdexamfetamine reduced binge eating behavior.”

Trial results showed the number of binge-eating days per week decreased significantly in the groups taking 50 mg and 70 mg doses daily compared to the placebo group. Over a month period, 42.2 percent of participants taking 50 mg doses of lisdexamfetamine and 50 percent of those taking 70 mg were able to completely eliminate BED behavior.

According to previous research, cognitive behavioral therapy and psychotherapy can reduce BE behavior, but implementation of these treatments has not been widespread. Consequently, many patients with BED are undertreated. There are currently no FDA-approved pharmacologic treatments for BED.

McElroy said she hopes confirmation of the findings in ongoing clinical trials result in improved pharmacologic treatment for BED.

“The results of this study need to be replicated in studies of larger groups of people with BED. Pharmaceutical company Shire is having discussions with the FDA about getting approval of lisdexamfetamine for the treatment of BED,” she said.

Study results are published online in JAMA Psychiatry.